The PlayStation 2 and Xbox ports of this game saw limited production for the Xbox and PlayStation 2 due to Capcom losing the Marvel license. Capcom 2 was later ported to the Dreamcast, Xbox, PlayStation 2, Xbox 360 and PlayStation 3. It is mainly seen in this game in the backgrounds and system effects, as well as Abyss's sphere.

It is the only game in the series to use the NAOMI system, which is used mostly for 3D games. The game also features 3 on 3 tag, compared to the 2 on 2 tag from previous games in the series. Changes were made to the air combo system and the button configuration was trimmed down to 4 main buttons and 2 assist buttons. With the (presumably) final installment of the series, Capcom simplified the engine so that it would be more accessible to casual players, in order to bring in new players, as interest in arcade fighting games had declined. Capcom 2 or MvC2) is the fourth game of the Marvel vs. Arcade, Dreamcast, PlayStation 2, Xbox, PlayStation 3, iOS, Android Marvel vs.

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